Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair

Jiajia Xu, Yiyun Wang, Mario A. Gomez-Salazar, Ginny Ching Yun Hsu, Stefano Negri, Zhao Li, Winters Hardy, Lijun Ding, Bruno Peault, Aaron W. James

Research output: Contribution to journalArticlepeer-review


Mesenchymal progenitor cells are broadly distributed across perivascular niches—an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tunica adventitia, the outer layer of blood vessel walls populated by cells with a fibroblastic morphology. The diversity and functions of (re)generative cells present in this outermost perivascular niche are under intense investigation; we have reviewed herein our current knowledge of adventitial cell potential with a somewhat narrow focus on bone formation. Antigens of interest to functionally segregate adventicytes are discussed, including CD10, CD107a, aldehyde dehydrogenase isoforms, and CD140a, among others. Purified adventicytes (such as CD10+, CD107alow, and CD140a+ cells) have stronger osteogenic potential and promote bone formation in vivo. Recent bone tissue engineering applications of adventitial cells are also presented. A better understanding of perivascular progenitor cell subsets may represent a beneficial advance for future efforts in tissue repair and bioengineering.

Original languageEnglish (US)
Pages (from-to)1427-1434
Number of pages8
JournalStem Cells
Issue number11
StatePublished - Nov 2021


  • ALDH
  • CD10
  • CD107a
  • CD140a
  • LAMP1
  • adipogenesis
  • adipose stem cell
  • exocytosis
  • mesenchymal stem cell
  • mesenchymal stromal cell
  • osteogenesis
  • perivascular stem cell
  • tunica adventitia

ASJC Scopus subject areas

  • General Medicine


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