Bombesin receptor antagonists differentiate receptor subtypes in rat brain

Ellen E. Ladenheim; Robert T. Jensen; Samuel A. Mantey; John E. Taylor; David H. Coy; Timothy H. Moran

doi:10.1016/0014-2999(93)90830-B

Bombesin receptor antagonists differentiate receptor subtypes in rat brain

Ellen E. Ladenheim, Robert T. Jensen, Samuel A. Mantey, John E. Taylor, David H. Coy, Timothy H. Moran

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Previous studies have shown that various bombesin receptor antagonists can distinguish between bombesin receptor subtypes in peripheral tissues. To determine whether these antagonists would be useful in differentiating bombesin receptor subtypes in the rat central nervous system, we used in vitro receptor autoradiography to examine the binding affinities of several bombesin receptor antagonists for two brain regions we had characterized as possessing distinct bombesin receptor subtypes. Our results demonstrate that, consistent with peripheral bombesin receptors, bombesin receptor subtypes in the rat brain can be differentiated by various bombesin receptor antagonists.

Original language	English (US)
Pages (from-to)	121-125
Number of pages	5
Journal	European Journal of Pharmacology
Volume	235
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(93)90830-B
State	Published - Apr 22 1993

Keywords

Bombesin
Gastrin-releasing peptide
Neuromedin B

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(93)90830-B

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title = "Bombesin receptor antagonists differentiate receptor subtypes in rat brain",

abstract = "Previous studies have shown that various bombesin receptor antagonists can distinguish between bombesin receptor subtypes in peripheral tissues. To determine whether these antagonists would be useful in differentiating bombesin receptor subtypes in the rat central nervous system, we used in vitro receptor autoradiography to examine the binding affinities of several bombesin receptor antagonists for two brain regions we had characterized as possessing distinct bombesin receptor subtypes. Our results demonstrate that, consistent with peripheral bombesin receptors, bombesin receptor subtypes in the rat brain can be differentiated by various bombesin receptor antagonists.",

keywords = "Bombesin, Gastrin-releasing peptide, Neuromedin B",

author = "Ladenheim, {Ellen E.} and Jensen, {Robert T.} and Mantey, {Samuel A.} and Taylor, {John E.} and Coy, {David H.} and Moran, {Timothy H.}",

note = "Funding Information: This work was partially supported by NIH Grant CA-45153 (D.H.",

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T1 - Bombesin receptor antagonists differentiate receptor subtypes in rat brain

AU - Ladenheim, Ellen E.

AU - Jensen, Robert T.

AU - Mantey, Samuel A.

AU - Taylor, John E.

AU - Coy, David H.

AU - Moran, Timothy H.

N1 - Funding Information: This work was partially supported by NIH Grant CA-45153 (D.H.

PY - 1993/4/22

Y1 - 1993/4/22

N2 - Previous studies have shown that various bombesin receptor antagonists can distinguish between bombesin receptor subtypes in peripheral tissues. To determine whether these antagonists would be useful in differentiating bombesin receptor subtypes in the rat central nervous system, we used in vitro receptor autoradiography to examine the binding affinities of several bombesin receptor antagonists for two brain regions we had characterized as possessing distinct bombesin receptor subtypes. Our results demonstrate that, consistent with peripheral bombesin receptors, bombesin receptor subtypes in the rat brain can be differentiated by various bombesin receptor antagonists.

AB - Previous studies have shown that various bombesin receptor antagonists can distinguish between bombesin receptor subtypes in peripheral tissues. To determine whether these antagonists would be useful in differentiating bombesin receptor subtypes in the rat central nervous system, we used in vitro receptor autoradiography to examine the binding affinities of several bombesin receptor antagonists for two brain regions we had characterized as possessing distinct bombesin receptor subtypes. Our results demonstrate that, consistent with peripheral bombesin receptors, bombesin receptor subtypes in the rat brain can be differentiated by various bombesin receptor antagonists.

KW - Bombesin

KW - Gastrin-releasing peptide

KW - Neuromedin B

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Bombesin receptor antagonists differentiate receptor subtypes in rat brain

Abstract

Keywords

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