TY - JOUR
T1 - Blueberry-enriched diet protects rat heart from ischemic damage
AU - Ahmet, Ismayil
AU - Spangler, Edward
AU - Shukitt-Hale, Barbara
AU - Juhaszova, Magdalena
AU - Sollott, Steven J.
AU - Joseph, James A.
AU - Ingram, Donald K.
AU - Talan, Mark
PY - 2009/6/18
Y1 - 2009/6/18
N2 - Objectives: To assess the cardioprotective properties of a blueberry enriched diet (BD). Background: Reactive oxygen species (ROS) play a major role in ischemia-related myocardial injury. The attempts to use synthetic antioxidants to block the detrimental effects of ROS have produced mixed or negative results precipitating the interest in natural products. Blueberries are readily available product with the highest antioxidant capacity among fruits and vegetables. Methods and Results: Following 3-mo of BD or a regular control diet (CD), the threshold for mitochondrial permeability transition (tMPT) was measured in isolated cardiomyocytes obtained from young male Fischer-344 rats. Compared to CD, BD resulted in a 24% increase (pMPT. The remaining animals were subjected to a permanent ligation of the left descending coronary artery. 24 hrs later resulting myocardial infarction (MI) in rats on BD was 22% less than in CD rats (p
AB - Objectives: To assess the cardioprotective properties of a blueberry enriched diet (BD). Background: Reactive oxygen species (ROS) play a major role in ischemia-related myocardial injury. The attempts to use synthetic antioxidants to block the detrimental effects of ROS have produced mixed or negative results precipitating the interest in natural products. Blueberries are readily available product with the highest antioxidant capacity among fruits and vegetables. Methods and Results: Following 3-mo of BD or a regular control diet (CD), the threshold for mitochondrial permeability transition (tMPT) was measured in isolated cardiomyocytes obtained from young male Fischer-344 rats. Compared to CD, BD resulted in a 24% increase (pMPT. The remaining animals were subjected to a permanent ligation of the left descending coronary artery. 24 hrs later resulting myocardial infarction (MI) in rats on BD was 22% less than in CD rats (p
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U2 - 10.1371/journal.pone.0005954
DO - 10.1371/journal.pone.0005954
M3 - Article
C2 - 19536295
AN - SCOPUS:67650132751
SN - 1932-6203
VL - 4
JO - PLoS One
JF - PLoS One
IS - 6
M1 - e5954
ER -