TY - JOUR
T1 - Blood–Brain Glucose Transport in the Conscious Rat
T2 - Comparison of the Intravenous and Intracarotid Injection Methods
AU - Gjedde, Albert
AU - Rasmussen, Mette
PY - 1980/12
Y1 - 1980/12
N2 - Abstract: The unidirectional transfer of d‐glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood–brain glucose transfer rate (Tmax) was 407 μ mol (100 g)–1 min–1 when measured by intravenous injection, and 352 μ mol (100 g)–1 min–1 when measured by intracarotid injection. The half–saturation constants (Km) were 7.8 mm and 16.8 HIM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.
AB - Abstract: The unidirectional transfer of d‐glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood–brain glucose transfer rate (Tmax) was 407 μ mol (100 g)–1 min–1 when measured by intravenous injection, and 352 μ mol (100 g)–1 min–1 when measured by intracarotid injection. The half–saturation constants (Km) were 7.8 mm and 16.8 HIM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.
KW - Blood‐brain barrier
KW - Blood‐brain glucose transfer
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U2 - 10.1111/j.1471-4159.1980.tb09012.x
DO - 10.1111/j.1471-4159.1980.tb09012.x
M3 - Article
C2 - 7441255
AN - SCOPUS:0019134270
SN - 0022-3042
VL - 35
SP - 1375
EP - 1381
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 6
ER -