Blood-brain barrier permeability during the development of experimental bacterial meningitis in the rat

Kwang Sik Kim, Carol A. Wass, Alan S. Cross

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


In an attempt to examine whether routes of bacterial entry into the central nervous system have any bearing on subsequent changes in blood-brain harrier permeability, we examined cerebrospinal fluid (CSF) penetration of circulating 125I-albumin in two different models of experimental meningitis due to K1 Escherichia coli, type III group B streptococcus, or Haemophilus influenzae type b in infant rats: hematogenous meningitis subsequent to subcutaneous inoculation of bacteria vs meningitis induced by direct inoculation of bacteria into the CSF via the cisterna magna. In the model of hematogenous meningitis, the mean CSF penetration was significantly greater in animals with H. influenzae type b meningitis than in those with meningitis due to K1 E. coli or type III group B streptococcus. In contrast, the mean CSF penetration was significantly enhanced in all animals with meningitis induced by intracisternal inoculation regardless of infecting pathogens. Tumor necrosis factor activity in CSF appeared to correlate with the functional penetration of circulating albumin across the blood-brain barrier in both models of experimental meningitis. These findings suggest that the alterations of blood- brain barrier permeability during development of experimental meningitis may vary for different models of inducing meningitis and that the mechanisms responsible for these different permeability changes may be multifactorial.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalExperimental Neurology
Issue number1
StatePublished - May 1997
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


Dive into the research topics of 'Blood-brain barrier permeability during the development of experimental bacterial meningitis in the rat'. Together they form a unique fingerprint.

Cite this