TY - JOUR
T1 - Blindness, Weakness, and Tingling
AU - Biotti, Damien
AU - Vignal, Catherine
AU - Sharshar, Tarek
AU - Gout, Oliver
AU - McCoy, Allison N.
AU - Miller, Neil R.
PY - 2012/11
Y1 - 2012/11
N2 - A previously healthy 50-year-old man complained of acute bilateral loss of vision over 24 hours associated with tingling of his hands and feet. During the first 48 hours of hospitalization, he evolved quadriplegia, facial diplegia, bulbar palsy, and respiratory distress requiring ventilator assistance. At the same time vision deteriorated to hand motions. Lumbar puncture, electromyography, and clinical findings were all consistent with Guillain-Barré syndrome. The diagnosis of concomitant bilateral optic neuritis was made. Tests for immunological, inflammatory, infectious, or genetic diseases were unremarkable. Within weeks, repeated treatments with intravenous immunoglobulin, plasmapheresis, and high-dose parenteral corticosteroids led to resolution of motor findings, although visual acuity improved only to 20/100 OD and count fingers at 6 feet OS. Guillain-Barré syndrome-associated optic neuritis is rare and may be associated with an underlying Mycoplasma pneumoniae infection.
AB - A previously healthy 50-year-old man complained of acute bilateral loss of vision over 24 hours associated with tingling of his hands and feet. During the first 48 hours of hospitalization, he evolved quadriplegia, facial diplegia, bulbar palsy, and respiratory distress requiring ventilator assistance. At the same time vision deteriorated to hand motions. Lumbar puncture, electromyography, and clinical findings were all consistent with Guillain-Barré syndrome. The diagnosis of concomitant bilateral optic neuritis was made. Tests for immunological, inflammatory, infectious, or genetic diseases were unremarkable. Within weeks, repeated treatments with intravenous immunoglobulin, plasmapheresis, and high-dose parenteral corticosteroids led to resolution of motor findings, although visual acuity improved only to 20/100 OD and count fingers at 6 feet OS. Guillain-Barré syndrome-associated optic neuritis is rare and may be associated with an underlying Mycoplasma pneumoniae infection.
KW - Acute demyelinating polyradiculoneuropathy
KW - Guillain-Barré syndrome
KW - Optic neuropathy
KW - Visual loss
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U2 - 10.1016/j.survophthal.2011.10.002
DO - 10.1016/j.survophthal.2011.10.002
M3 - Review article
C2 - 22398335
AN - SCOPUS:84867555770
SN - 0039-6257
VL - 57
SP - 565
EP - 572
JO - Survey of ophthalmology
JF - Survey of ophthalmology
IS - 6
ER -