Abstract
Objective: To examine the analytic role of arsenic exposure on cancer mortality among the low-dose (well water arsenic level 500 μg/L, but use of the village mean or the maximum did not. Poisson analyses using mean or maximum arsenic levels showed significant negative cancer slope factors for models of bladder cancers and of bladder and lung cancers combined. Inclusion of the southwest Taiwan regional data did not change the findings when the model contained an explanatory variable for non-arsenic differences. A positive slope could only be generated by including the comparison population as a separate data point with the assumption of zero arsenic exposure from drinking water and eliminating the variable for non-arsenic risk factors. Conclusion: The cancer rates are higher among the low-dose (
Original language | English (US) |
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Pages (from-to) | 147-156 |
Number of pages | 10 |
Journal | Regulatory Toxicology and Pharmacology |
Volume | 65 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2013 |
Keywords
- Arsenic
- Blackfoot-disease area
- Bladder cancer
- Dose-response
- Lung cancer
ASJC Scopus subject areas
- Toxicology