Abstract
Progressive multifocal leukoencephalopathy (PML) is caused by JC polyomavirus (JCPyV). Because a reciprocal relationship has been described between antibody levels to JCPyV and BK polyomavirus (BKPyV), we performed a nested case control study with pre-diagnostic serum samples from HIV infected subjects to examine the relationship between BKPyV capsid antibodies and the risk of PML. Serum samples collected 0.5-2 years before PML diagnosis from 25 cases (66 samples) and 80 matched controls (204 samples) were tested in ELISA for JCPyV, BKPyV type 1 and type 4 capsid antibodies. High levels of BKPyV 1 and 4 antibodies were associated with a lower risk of PML (BKPyV 1 OR, 0.56, 95% CI, 0.35-0.89; BKPyV 4 OR, 0.40, 95% CI, 0.24-0.0.67). Our study demonstrates that antibodies to BKPyV capsids are an immunological marker of protection against development of PML. Further studies are needed to define the mechanism.
Original language | English (US) |
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Pages (from-to) | 467-472 |
Number of pages | 6 |
Journal | Virology |
Volume | 485 |
DOIs | |
State | Published - Nov 1 2015 |
Keywords
- BK polyomavirus
- Cohort study
- Human immunodeficiency virus
- JC polyomavirus
- Progressive multifocal leukoencephalopathy
- Viral serology
ASJC Scopus subject areas
- Virology