TY - JOUR
T1 - Bk and jc virus infections in recipients of bone marrow thinsplants
AU - Arthur, Ray R.
AU - Shah, Keerti V.
AU - Charache, Patricia
AU - Saral, Rein
N1 - Funding Information:
This work was supported by grants CA-13478,CA-44962, CA-06973, and CA-15396from the National Cancer Institute and by funds from the Harley W. Howell Foundation.
PY - 1988/9
Y1 - 1988/9
N2 - Fifty-five recipients of bone marrow transplants were monitored prospectively for urinary excretion of BK (BKV) and JC (JCV) viruses and for infections with other viruses. For both BKV and JCV, viruria occurred exclusively in patients who were seropositive at transplantation, a finding indicating that shedding of virus was very likely the result of reactivation. BKV reactivation, which occurred in 26 (55%) of 47 BKV-seropositive patients, was far more common than JCV reactivation, which was detected in only two (7%) of 30 JCV-seropositive patients (P <.0001). In most patients, BK viruria began two to eight weeks after transplantation and resolved spontaneously after a two- to three- week period. Posttransplantation, there was a temporal pattern in the onsets of infection with the different viruses; herpes simplex virus infections occurred first (mean, 7 d), followed by BKV infections (mean, 33 d) and then cytomegalovirus infections (mean, 51 d). BK viruria was associated with hemorrhagic cystitis.
AB - Fifty-five recipients of bone marrow transplants were monitored prospectively for urinary excretion of BK (BKV) and JC (JCV) viruses and for infections with other viruses. For both BKV and JCV, viruria occurred exclusively in patients who were seropositive at transplantation, a finding indicating that shedding of virus was very likely the result of reactivation. BKV reactivation, which occurred in 26 (55%) of 47 BKV-seropositive patients, was far more common than JCV reactivation, which was detected in only two (7%) of 30 JCV-seropositive patients (P <.0001). In most patients, BK viruria began two to eight weeks after transplantation and resolved spontaneously after a two- to three- week period. Posttransplantation, there was a temporal pattern in the onsets of infection with the different viruses; herpes simplex virus infections occurred first (mean, 7 d), followed by BKV infections (mean, 33 d) and then cytomegalovirus infections (mean, 51 d). BK viruria was associated with hemorrhagic cystitis.
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U2 - 10.1093/infdis/158.3.563
DO - 10.1093/infdis/158.3.563
M3 - Article
C2 - 2842404
AN - SCOPUS:0023820732
SN - 0022-1899
VL - 158
SP - 563
EP - 569
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -