Bisfosfonaten bij behandeling en preventie van botmetastasen

Translated title of the contribution: Bisphosphonates in treatment and prevention of bone metastases

K. Hoekman, A. T M Van Holten-Verzantvoort, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Bone metastases occur frequently in cancer and are commonly associated with bone degradation due to the tumoral production of factors which stimulate the development and activation of osteoclasts. During osteolysis growth factors are released which stimulate tumour growth. Bisphosphonates inhibit osteoclastic bone resorption. Recently, in several large randomised studies of patients with multiple myeloma or bone metastases of breast cancer, long-term treatment with clodronate or pamidronate gave significant bone protection.

Translated title of the contributionBisphosphonates in treatment and prevention of bone metastases
Original languageDutch
Pages (from-to)2217-2222
Number of pages6
JournalNederlands Tijdschrift voor Geneeskunde
Issue number46
StatePublished - Nov 1997
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Bisphosphonates in treatment and prevention of bone metastases'. Together they form a unique fingerprint.

Cite this