Bisphosphonates and Osteonecrosis: Potential Treatment or Serious Complication?

Robin N. Goytia, Andrew Salama, Harpal S. Khanuja

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


They are commonly used to treat osteoporosis and other diseases that involve osteoclast-mediated bone resorption, including Paget's disease and multiple myeloma. Their use in treating osteonecrosis of the femoral head has been studied and theoretically holds promise. There are complications associated with these medications, however, including the development of osteonecrosis in the jaw.

Original languageEnglish (US)
Pages (from-to)223-234
Number of pages12
JournalOrthopedic Clinics of North America
Issue number2
StatePublished - Apr 1 2009


  • Avascular necrosis
  • Bisphosphonates
  • Osteonecrosis
  • Osteonecrosis of the femoral head
  • Osteonecrosis of the jaw

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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