Bisphosphonate-associated scleritis: A case report and review

Sophia Leung; Bimal H. Ashar; Redonda G. Miller

doi:10.1097/01.SMJ.0000152753.80490.9F

Bisphosphonate-associated scleritis: A case report and review

Sophia Leung, Bimal H. Ashar, Redonda G. Miller

School of Medicine

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

An 86-year-old female was treated for osteoporosis with alendronate, an aminobisphosphonate. Six weeks after alendronate therapy began, scleritis developed in the patient's right eye. The alendronate was discontinued, and, with the administration of prednisone, the symptoms of scleritis fully resolved. Rechallenge resulted in recurrence of the symptoms. Bisphosphonates are commonly used in the management of osteoporosis and are generally safe agents. Rarely, they have been linked with ocular inflammation. This case report reviews the literature on the ocular effects of bisphosphonates and discusses a possible mechanism for the association.

Original language	English (US)
Pages (from-to)	733-735
Number of pages	3
Journal	Southern medical journal
Volume	98
Issue number	7
DOIs	https://doi.org/10.1097/01.SMJ.0000152753.80490.9F
State	Published - Jul 2005

Keywords

Alendronate
Bisphosphonate
Scleritis
Uveitis

ASJC Scopus subject areas

General Medicine

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10.1097/01.SMJ.0000152753.80490.9F

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title = "Bisphosphonate-associated scleritis: A case report and review",

abstract = "An 86-year-old female was treated for osteoporosis with alendronate, an aminobisphosphonate. Six weeks after alendronate therapy began, scleritis developed in the patient's right eye. The alendronate was discontinued, and, with the administration of prednisone, the symptoms of scleritis fully resolved. Rechallenge resulted in recurrence of the symptoms. Bisphosphonates are commonly used in the management of osteoporosis and are generally safe agents. Rarely, they have been linked with ocular inflammation. This case report reviews the literature on the ocular effects of bisphosphonates and discusses a possible mechanism for the association.",

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T2 - A case report and review

AU - Leung, Sophia

AU - Ashar, Bimal H.

AU - Miller, Redonda G.

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N2 - An 86-year-old female was treated for osteoporosis with alendronate, an aminobisphosphonate. Six weeks after alendronate therapy began, scleritis developed in the patient's right eye. The alendronate was discontinued, and, with the administration of prednisone, the symptoms of scleritis fully resolved. Rechallenge resulted in recurrence of the symptoms. Bisphosphonates are commonly used in the management of osteoporosis and are generally safe agents. Rarely, they have been linked with ocular inflammation. This case report reviews the literature on the ocular effects of bisphosphonates and discusses a possible mechanism for the association.

AB - An 86-year-old female was treated for osteoporosis with alendronate, an aminobisphosphonate. Six weeks after alendronate therapy began, scleritis developed in the patient's right eye. The alendronate was discontinued, and, with the administration of prednisone, the symptoms of scleritis fully resolved. Rechallenge resulted in recurrence of the symptoms. Bisphosphonates are commonly used in the management of osteoporosis and are generally safe agents. Rarely, they have been linked with ocular inflammation. This case report reviews the literature on the ocular effects of bisphosphonates and discusses a possible mechanism for the association.

KW - Alendronate

KW - Bisphosphonate

KW - Scleritis

KW - Uveitis

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Bisphosphonate-associated scleritis: A case report and review

Abstract

Keywords

ASJC Scopus subject areas

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