Abstract
Bis(N,N-dimethylcarbamoyloxymethyl) 2', 3'-dideoxyuridine 5'- monophosphate (DM2-ddUMP) (1a) was synthesized as a potential membrane- permeable prodrug of ddUMP (3). Unlike the bis(pivaloyloxymethyl) analog, 1b, 1a was completely resistant to degradation by plasma enzymes - a property that should enhance its bioavailability.
Original language | English (US) |
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Pages (from-to) | 607-610 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 40 |
Issue number | 4 |
DOIs | |
State | Published - Jan 22 1999 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery