Birdshot Chorioretinitis in Patients Aged 80 and Older

Louis Debillon; Jennifer E. Thorne; Elodie Bousquet; Pierre Duraffour; Souhila Kecili; Dominique Monnet; Antoine P. Brézin

doi:10.1080/09273948.2023.2215322

Birdshot Chorioretinitis in Patients Aged 80 and Older

Louis Debillon, Jennifer E. Thorne, Elodie Bousquet, Pierre Duraffour, Souhila Kecili, Dominique Monnet, Antoine P. Brézin

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over. Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over. Methods: Patients were assessed in a standardized manner. Confluent atrophy was defined as hypoautofluorescent spots on fundus autofluorescence (FAF). Results: We included 39 (8.8%) of the 442 enrolled CO-BIRD patients. The mean age was 83.8 ± 3.7 years. The mean logMAR BCVA was 0.52 ± 0.76, with 30 patients (76.9%) having 20/40 or better in at least one eye. Thirty-five (89.7%) patients were receiving no treatment. Confluent atrophy in the posterior pole, disrupted retrofoveal ellipsoid zone and choroidal neovascularization were associated with logMAR BCVA >0.3 (p <.0001). Conclusion: In patients aged 80 and over we observed a striking heterogeneity of outcomes, but most retained a BCVA that allowed them to drive.

Original language	English (US)
Pages (from-to)	1212-1217
Number of pages	6
Journal	Ocular Immunology and Inflammation
Volume	32
Issue number	7
DOIs	https://doi.org/10.1080/09273948.2023.2215322
State	Published - 2024

Keywords

Birdshot chorioretinitis
choroid
immunosuppressive therapy
long-term
posterior uveitis

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

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10.1080/09273948.2023.2215322

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title = "Birdshot Chorioretinitis in Patients Aged 80 and Older",

abstract = "Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over. Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over. Methods: Patients were assessed in a standardized manner. Confluent atrophy was defined as hypoautofluorescent spots on fundus autofluorescence (FAF). Results: We included 39 (8.8%) of the 442 enrolled CO-BIRD patients. The mean age was 83.8 ± 3.7 years. The mean logMAR BCVA was 0.52 ± 0.76, with 30 patients (76.9%) having 20/40 or better in at least one eye. Thirty-five (89.7%) patients were receiving no treatment. Confluent atrophy in the posterior pole, disrupted retrofoveal ellipsoid zone and choroidal neovascularization were associated with logMAR BCVA >0.3 (p <.0001). Conclusion: In patients aged 80 and over we observed a striking heterogeneity of outcomes, but most retained a BCVA that allowed them to drive.",

keywords = "Birdshot chorioretinitis, choroid, immunosuppressive therapy, long-term, posterior uveitis",

author = "Louis Debillon and Thorne, {Jennifer E.} and Elodie Bousquet and Pierre Duraffour and Souhila Kecili and Dominique Monnet and Br{\'e}zin, {Antoine P.}",

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year = "2024",

doi = "10.1080/09273948.2023.2215322",

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AU - Debillon, Louis

AU - Thorne, Jennifer E.

AU - Bousquet, Elodie

AU - Duraffour, Pierre

AU - Kecili, Souhila

AU - Monnet, Dominique

AU - Brézin, Antoine P.

PY - 2024

Y1 - 2024

N2 - Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over. Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over. Methods: Patients were assessed in a standardized manner. Confluent atrophy was defined as hypoautofluorescent spots on fundus autofluorescence (FAF). Results: We included 39 (8.8%) of the 442 enrolled CO-BIRD patients. The mean age was 83.8 ± 3.7 years. The mean logMAR BCVA was 0.52 ± 0.76, with 30 patients (76.9%) having 20/40 or better in at least one eye. Thirty-five (89.7%) patients were receiving no treatment. Confluent atrophy in the posterior pole, disrupted retrofoveal ellipsoid zone and choroidal neovascularization were associated with logMAR BCVA >0.3 (p <.0001). Conclusion: In patients aged 80 and over we observed a striking heterogeneity of outcomes, but most retained a BCVA that allowed them to drive.

AB - Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over. Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over. Methods: Patients were assessed in a standardized manner. Confluent atrophy was defined as hypoautofluorescent spots on fundus autofluorescence (FAF). Results: We included 39 (8.8%) of the 442 enrolled CO-BIRD patients. The mean age was 83.8 ± 3.7 years. The mean logMAR BCVA was 0.52 ± 0.76, with 30 patients (76.9%) having 20/40 or better in at least one eye. Thirty-five (89.7%) patients were receiving no treatment. Confluent atrophy in the posterior pole, disrupted retrofoveal ellipsoid zone and choroidal neovascularization were associated with logMAR BCVA >0.3 (p <.0001). Conclusion: In patients aged 80 and over we observed a striking heterogeneity of outcomes, but most retained a BCVA that allowed them to drive.

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KW - posterior uveitis

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Birdshot Chorioretinitis in Patients Aged 80 and Older

Abstract

Keywords

ASJC Scopus subject areas

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