Bipolar disorder as maladaptive arousal

Dean F. MacKinnon

doi:10.1196/annals.1417.000

Bipolar disorder as maladaptive arousal

Dean F. MacKinnon

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Bipolar disorder can be understood as a disorder of behavioral regulation. Manic and depressed individuals are impaired in the titration of appetitive arousal, possibly at the level of neuronal plasticity. An experiment in which fixed 5% CO₂ stimulates respiration and blocks satiety tests the regulation of appetitive arousal. In preliminary analysis of data from 35 individuals (24 with bipolar disorder) individuals with bipolar disorder were more likely to fail to find a stable state of respiratory adjustment to CO ₂. If confirmed, the unstable respiratory response to CO₂ may prove useful as a bipolar-disorder endophenotype.

Original language	English (US)
Pages (from-to)	185-189
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1129
DOIs	https://doi.org/10.1196/annals.1417.000
State	Published - May 2008

Keywords

Arousal
Behavior
Bipolar disorder
Conditioning
Endophenotype
Plasticity
Respiration

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1196/annals.1417.000

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AB - Bipolar disorder can be understood as a disorder of behavioral regulation. Manic and depressed individuals are impaired in the titration of appetitive arousal, possibly at the level of neuronal plasticity. An experiment in which fixed 5% CO2 stimulates respiration and blocks satiety tests the regulation of appetitive arousal. In preliminary analysis of data from 35 individuals (24 with bipolar disorder) individuals with bipolar disorder were more likely to fail to find a stable state of respiratory adjustment to CO 2. If confirmed, the unstable respiratory response to CO2 may prove useful as a bipolar-disorder endophenotype.

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KW - Conditioning

KW - Endophenotype

KW - Plasticity

KW - Respiration

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Bipolar disorder as maladaptive arousal

Abstract

Keywords

ASJC Scopus subject areas

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