Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model

Eric A. Sobie; Matthew G. Fishler; Leslie Tung

Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model

Eric A. Sobie, Matthew G. Fishler, Leslie Tung

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

A model of an isolated cardiac cell in a uniform electric field was used to study the differences in action potential prolongation produced by monophasic and biphasic field stimulation. Repolarization times induced by shocks of varying strengths delivered at different times in the relative refractory period were measured. Monophasic shocks were found to produce greater average prolongation, but the standard deviation of the biphasic repolarization times was less. The more uniform response caused by the biphasic pulse may help to explain the greater efficacy of biphasic waveforms in defibrillation.

Original language	English (US)
Pages (from-to)	257-258
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	17
Issue number	1
State	Published - Dec 1 1995
Event	Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can Duration: Sep 20 1995 → Sep 23 1995

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model. / Sobie, Eric A.; Fishler, Matthew G.; Tung, Leslie.
In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 17, No. 1, 01.12.1995, p. 257-258.

Research output: Contribution to journal › Conference article › peer-review

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N2 - A model of an isolated cardiac cell in a uniform electric field was used to study the differences in action potential prolongation produced by monophasic and biphasic field stimulation. Repolarization times induced by shocks of varying strengths delivered at different times in the relative refractory period were measured. Monophasic shocks were found to produce greater average prolongation, but the standard deviation of the biphasic repolarization times was less. The more uniform response caused by the biphasic pulse may help to explain the greater efficacy of biphasic waveforms in defibrillation.

AB - A model of an isolated cardiac cell in a uniform electric field was used to study the differences in action potential prolongation produced by monophasic and biphasic field stimulation. Repolarization times induced by shocks of varying strengths delivered at different times in the relative refractory period were measured. Monophasic shocks were found to produce greater average prolongation, but the standard deviation of the biphasic repolarization times was less. The more uniform response caused by the biphasic pulse may help to explain the greater efficacy of biphasic waveforms in defibrillation.

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JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

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Biphasic shocks induce more uniform repolarization than monophasic shocks in a cardiac cellular field excitation model

Abstract

ASJC Scopus subject areas

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