Biosynthesis of glycosyl phosphatidylinositol protein anchors

Tamara L. Doering, Jayne Raper, Laurence U. Buxbaum, Gerald W. Hart, Paul T. Englund

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Glycosyl phosphatidylinositols (GPIs) serve as membrane anchors for many plasma membrane proteins in all eukaryotic cells. African trypanosomes provide an ideal system for investigating GPIs, because these parasites produce extremely large quantities to anchor their major surface protein, the variant surface glycoprotein. Through radiolabeling methods and use of a cell-free system, the major features of the trypanosome GPI biosynthetic pathway have been elucidated. It is likely that these techniques, successful in the study of trypanosome GPIs, will be applicable to other eukaryotic cells.

Original languageEnglish (US)
Pages (from-to)288-296
Number of pages9
Issue number3
StatePublished - Dec 1990
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Biosynthesis of glycosyl phosphatidylinositol protein anchors'. Together they form a unique fingerprint.

Cite this