Bioprosthetic valve thrombosis in carcinoid heart disease

Kimberly Naden Hollander, Brijen L. Joshi, Brijen L. Joshi

Research output: Contribution to journalArticlepeer-review


Tricuspid regurgitation in carcinoid syndrome leads to significant morbidity and mortality that may warrant a tricuspid valve replacement. However, for patients with high serotonin levels and known hypercoagulable risks, the optimum timing for surgery and postoperative anticoagulation approaches remain unclear. High serotonin-Triggered hypercoagulability makes prosthetic valves susceptible to thrombosis. Despite appropriate management with a somatostatin analog, some patients continue to have high markers of serotonin that causes platelet aggregation and rapid clot formation. In severely symptomatic patients who require valve surgery, it may not be feasible to postpone surgery until these metabolites are normalized, which may add a substantial risk for postoperative valve thrombosis to an otherwise uneventful procedure. In some, there is a significant need to predict and prevent bioprosthetic valve thrombosis in carcinoid heart disease and to identify best anticoagulation practices across a spectrum of its complex coagulation dynamics and clinical presentation.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalAnnals of Cardiac Anaesthesia
Issue number1
StatePublished - Jan 1 2019


  • Carcinoid heart disease
  • heart valve prosthesis
  • serotonin
  • thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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