Bionized Nanoferrite Particles Alter the Course of Experimental Cryptococcus neoformans Pneumonia

Livia C. Liporagi Lopes; Preethi Korangath; Samuel R. Dos Santos; Kathleen L. Gabrielson; Robert Ivkov; Arturo Casadevall

doi:10.1128/aac.02399-21

Bionized Nanoferrite Particles Alter the Course of Experimental Cryptococcus neoformans Pneumonia

Livia C. Liporagi Lopes, Preethi Korangath, Samuel R. Dos Santos, Kathleen L. Gabrielson, Robert Ivkov, Arturo Casadevall

Research output: Contribution to journal › Article › peer-review

Abstract

Cryptococcosis is a devastating fungal disease associated with high morbidity and mortality even when treated with antifungal drugs. Bionized nanoferrite (BNF) nanoparticles are powerful immunomodulators, but their efficacy for infectious diseases has not been investigated. Administration of BNF nanoparticles to mice with experimental cryptococcal pneumonia altered the outcome of infection in a dose response manner as measured by CFU and survival. The protective effects were higher at lower doses, with reductions in IL-2, IL-4, and TNF-a, consistent with immune modulation whereby reductions in inflammation translate into reduced host damage, clearance of infection, and longer survival.

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	66
Issue number	4
DOIs	https://doi.org/10.1128/aac.02399-21
State	Published - Apr 2022

Keywords

cryptococcal pneumonia
immune system
iron oxide nanoparticles

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/aac.02399-21

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title = "Bionized Nanoferrite Particles Alter the Course of Experimental Cryptococcus neoformans Pneumonia",

abstract = "Cryptococcosis is a devastating fungal disease associated with high morbidity and mortality even when treated with antifungal drugs. Bionized nanoferrite (BNF) nanoparticles are powerful immunomodulators, but their efficacy for infectious diseases has not been investigated. Administration of BNF nanoparticles to mice with experimental cryptococcal pneumonia altered the outcome of infection in a dose response manner as measured by CFU and survival. The protective effects were higher at lower doses, with reductions in IL-2, IL-4, and TNF-a, consistent with immune modulation whereby reductions in inflammation translate into reduced host damage, clearance of infection, and longer survival.",

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AU - Liporagi Lopes, Livia C.

AU - Korangath, Preethi

AU - Dos Santos, Samuel R.

AU - Gabrielson, Kathleen L.

AU - Ivkov, Robert

AU - Casadevall, Arturo

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AB - Cryptococcosis is a devastating fungal disease associated with high morbidity and mortality even when treated with antifungal drugs. Bionized nanoferrite (BNF) nanoparticles are powerful immunomodulators, but their efficacy for infectious diseases has not been investigated. Administration of BNF nanoparticles to mice with experimental cryptococcal pneumonia altered the outcome of infection in a dose response manner as measured by CFU and survival. The protective effects were higher at lower doses, with reductions in IL-2, IL-4, and TNF-a, consistent with immune modulation whereby reductions in inflammation translate into reduced host damage, clearance of infection, and longer survival.

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Bionized Nanoferrite Particles Alter the Course of Experimental Cryptococcus neoformans Pneumonia

Abstract

Keywords

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