TY - JOUR
T1 - Biometric and molecular characterization of clinically diagnosed posterior microphthalmos
AU - Nowilaty, Sawsan R.
AU - Khan, Arif O.
AU - Aldahmesh, Mohammed A.
AU - Tabbara, Khalid F.
AU - Al-Amri, Abdullah
AU - Alkuraya, Fowzan S.
PY - 2013/2
Y1 - 2013/2
N2 - Purpose: To biometrically and molecularly characterize clinically diagnosed posterior microphthalmos. Design: Prospective case series. Methods: Twenty-five affected patients from 13 families diagnosed by ophthalmologists experienced with the condition at the King Khaled Eye Specialist Hospital were studied. All participants underwent axial length measurement, keratometry, corneal pachymetry, and candidate gene analysis (MFRP, PRSS56). Main outcome measures were the results of ocular biometry and gene analysis. Results: All patients (2-47 years of age) had high hyperopia, normal-appearing anterior segments, posterior chamber foreshortening, and characteristic papillomacular folds/wrinkles. For the right eye, mean cycloplegic refraction was +15.09 diopters (D) (range 9.88-18.75). Axial length (mean 16.25 mm [range 14.88-19.88]) had strong inverse correlation (Pearson coefficient -0.88, P
AB - Purpose: To biometrically and molecularly characterize clinically diagnosed posterior microphthalmos. Design: Prospective case series. Methods: Twenty-five affected patients from 13 families diagnosed by ophthalmologists experienced with the condition at the King Khaled Eye Specialist Hospital were studied. All participants underwent axial length measurement, keratometry, corneal pachymetry, and candidate gene analysis (MFRP, PRSS56). Main outcome measures were the results of ocular biometry and gene analysis. Results: All patients (2-47 years of age) had high hyperopia, normal-appearing anterior segments, posterior chamber foreshortening, and characteristic papillomacular folds/wrinkles. For the right eye, mean cycloplegic refraction was +15.09 diopters (D) (range 9.88-18.75). Axial length (mean 16.25 mm [range 14.88-19.88]) had strong inverse correlation (Pearson coefficient -0.88, P
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U2 - 10.1016/j.ajo.2012.08.016
DO - 10.1016/j.ajo.2012.08.016
M3 - Article
C2 - 23127749
AN - SCOPUS:84872307943
SN - 0002-9394
VL - 155
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 2
ER -