Biomechanically-constrained 4D estimation of myocardial motion

Hari Sundar, Christos Davatzikos, George Biros

Research output: Chapter in Book/Report/Conference proceedingConference contribution

24 Scopus citations


We propose a method for the analysis of cardiac images with the goal of reconstructing the motion of the ventricular walls. The main feature of our method is that the inversion parameter field is the active contraction of the myocardial fibers. This is accomplished with a biophysically-constrained, four-dimensional (space plus time) formulation that aims to complement information that can be gathered from the images by a priori knowledge of cardiac mechanics. Our main hypothesis is that by incorporating biophysical information, we can generate more informative priors and thus, more accurate predictions of the ventricular wall motion. In this paper, we outline the formulation, discuss the computational methodology for solving the inverse motion estimation, and present preliminary validation using synthetic and tagged MR images. The overall method uses patient-specific imaging and fiber information to reconstruct the motion. In these preliminary tests, we verify the implementation and conduct a parametric study to test the sensitivity of the model to material properties perturbations, model errors, and incomplete and noisy observations.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI2009 - 12th International Conference, Proceedings
Number of pages9
EditionPART 2
StatePublished - 2009
Externally publishedYes
Event12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009 - London, United Kingdom
Duration: Sep 20 2009Sep 24 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume5762 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
Country/TerritoryUnited Kingdom

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


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