Biomaterials engineered for integration

Lorenzo Moroni, Jennifer H. Elisseeff

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


As tissue engineering and regenerative medicine are staged to enter the medical care setting, the integration of these newly formed tissues with themselves and the surrounding natural environment of the treated patients is of paramount importance. Although cells alone have undoubtedly obtained a certain success as therapies for a number of different diseases, it is still unclear whether they form new tissues or they stimulate the local cells to restore tissue continuity. In both cases, the resulting outcome is often poorly connected with the surrounding environment and functionality is impaired after few months. True integration can be achieved by designing smart templates made of biomaterials that not only act as scaffolds for cells to adhere and form new tissue, but also provide cues and signals to promote functional tissue connections. Criteria to engineer biomaterials for integration and methodologies used to assess effective connection with host tissues are reviewed.

Original languageEnglish (US)
Pages (from-to)44-51
Number of pages8
JournalMaterials Today
Issue number5
StatePublished - May 2008

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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