Biomaterials-based approaches for cardiac regeneration

Samhita Vasu, Justin Zhou, Jeffrey Chen, Peter V. Johnston, Deok Ho Kim

Research output: Contribution to journalReview articlepeer-review


The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as that involve bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in clinical trials and animal studies in improving cardiac function, promoting angiogenesis, and reducing adverse immune response. This review will focus on current clinical studies of three contemporary biomaterials-based approaches for cardiac regeneration (extracellular vesicles, injectable hydrogels, and cardiac patches), remaining challenges and shortcomings to be overcome, and future directions for the use of biomaterials to promote cardiac regeneration.

Original languageEnglish (US)
Article numbere118
JournalKorean Circulation Journal
StatePublished - Sep 2021


  • Cardiovascular diseases
  • Extracellular vesicles
  • Heart failure
  • Tissue engineering

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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