TY - JOUR
T1 - Biomarkers of sickle cell nephropathy in Senegal
AU - Ndour, El Hadji Malick
AU - Mnika, Khuthala
AU - Tall, Fatou Guèye
AU - Seck, Moussa
AU - Ly, Indou Dème
AU - Nembaware, Victoria
AU - Mazandu, Gaston Kuzamunu
AU - Bassène, Hélène Ange Thérèse Sagna
AU - Dione, Rokhaya
AU - Ndongo, Aliou Abdoulaye
AU - Diop, Jean Pascal Demba
AU - Barry, Nènè Oumou Kesso
AU - Djité, Moustapha
AU - Diallo, Rokhaya Ndiaye
AU - Guèye, Papa Madièye
AU - Diop, Saliou
AU - Diagne, Ibrahima
AU - Cissé, Aynina
AU - Wonkam, Ambroise
AU - Sall, Philomène Lopez
N1 - Funding Information:
The clinical chemistry experiments of the study were in part funded by The African Center of Excellence for Maternal and Child Health «Centre d'Excellence Africain pour la Santé de la Mère et de l'Enfant (CEA-SAMEF, http://ceasamef.sn, No 000099/2018/JCM/KND)», Cheikh Anta Diop University of Dakar, Senegal. The molecular experiments of the study were funded by SADaCC (https://www.sickleinafrica.org) at the Division of Human Genetics, Faculty for Health Sciences, University of Cape Town, South Africa. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
Copyright: © 2022 Ndour et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/11
Y1 - 2022/11
N2 - Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 -test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4-77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3% vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA.
AB - Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 -test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4-77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3% vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA.
UR - http://www.scopus.com/inward/record.url?scp=85142366514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85142366514&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0273745
DO - 10.1371/journal.pone.0273745
M3 - Article
C2 - 36409722
AN - SCOPUS:85142366514
SN - 1932-6203
VL - 17
JO - PloS one
JF - PloS one
IS - 11 November
M1 - e0273745
ER -