Biomarkers of Esophageal Adenocarcinoma and Barrett's Esophagus

Damian T. McManus, Andreea Olaru, Stephen J. Meltzer

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations


The rising incidence and poor prognosis of esophageal adenocarcinoma in the Western world have intensified research efforts into earlier methods of detection of this disease and its relationship to Barrett's esophagus. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and serum-based disease biomarkers have emerged. The epidemiology and pathogenesis of esophageal adenocarcinoma are outlined. Tissue biomarkers allowing risk stratification of Barrett's are reviewed as well as strategies currently being used to discover novel biomarkers that will facilitate the early detection of esophageal adenocarcinoma. Finally, the uses of biomarkers as predictive tests for targeted treatments and as surrogate endpoints; in chemoprevention trials are considered.

Original languageEnglish (US)
Pages (from-to)1561-1569
Number of pages9
JournalCancer Research
Issue number5
StatePublished - Mar 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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