Biology of Human Papillomavirus-Related Oropharyngeal Cancer

Jason D. Howard; Christine H. Chung

doi:10.1016/j.semradonc.2012.03.002

Biology of Human Papillomavirus-Related Oropharyngeal Cancer

Jason D. Howard, Christine H. Chung

School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Recent data show that human papillomavirus-positive oropharyngeal cancer (OPC) has a distinct biological and clinical behavior compared with human papillomavirus-negative OPC. As this subset of head and neck cancer represents an increasing public health concern, a thorough understanding of the causative and mechanistic differences between these diseases and how these distinctions impact clinical treatment is required. In this review, we will summarize recent data in epidemiology, the mechanism of viral carcinogenesis and differences in tumor biology that may provide insights to improve the clinical management of patients with human papillomavirus-positive OPC.

Original language	English (US)
Pages (from-to)	187-193
Number of pages	7
Journal	Seminars in Radiation Oncology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.semradonc.2012.03.002
State	Published - Jul 2012

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/j.semradonc.2012.03.002

Cite this

@article{e12d7ea2c787411092e22c209b0954dd,

title = "Biology of Human Papillomavirus-Related Oropharyngeal Cancer",

abstract = "Recent data show that human papillomavirus-positive oropharyngeal cancer (OPC) has a distinct biological and clinical behavior compared with human papillomavirus-negative OPC. As this subset of head and neck cancer represents an increasing public health concern, a thorough understanding of the causative and mechanistic differences between these diseases and how these distinctions impact clinical treatment is required. In this review, we will summarize recent data in epidemiology, the mechanism of viral carcinogenesis and differences in tumor biology that may provide insights to improve the clinical management of patients with human papillomavirus-positive OPC.",

author = "Howard, {Jason D.} and Chung, {Christine H.}",

year = "2012",

month = jul,

doi = "10.1016/j.semradonc.2012.03.002",

language = "English (US)",

volume = "22",

pages = "187--193",

journal = "Seminars in Radiation Oncology",

issn = "1053-4296",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - Biology of Human Papillomavirus-Related Oropharyngeal Cancer

AU - Howard, Jason D.

AU - Chung, Christine H.

PY - 2012/7

Y1 - 2012/7

N2 - Recent data show that human papillomavirus-positive oropharyngeal cancer (OPC) has a distinct biological and clinical behavior compared with human papillomavirus-negative OPC. As this subset of head and neck cancer represents an increasing public health concern, a thorough understanding of the causative and mechanistic differences between these diseases and how these distinctions impact clinical treatment is required. In this review, we will summarize recent data in epidemiology, the mechanism of viral carcinogenesis and differences in tumor biology that may provide insights to improve the clinical management of patients with human papillomavirus-positive OPC.

AB - Recent data show that human papillomavirus-positive oropharyngeal cancer (OPC) has a distinct biological and clinical behavior compared with human papillomavirus-negative OPC. As this subset of head and neck cancer represents an increasing public health concern, a thorough understanding of the causative and mechanistic differences between these diseases and how these distinctions impact clinical treatment is required. In this review, we will summarize recent data in epidemiology, the mechanism of viral carcinogenesis and differences in tumor biology that may provide insights to improve the clinical management of patients with human papillomavirus-positive OPC.

UR - http://www.scopus.com/inward/record.url?scp=84862147656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862147656&partnerID=8YFLogxK

U2 - 10.1016/j.semradonc.2012.03.002

DO - 10.1016/j.semradonc.2012.03.002

M3 - Article

C2 - 22687942

AN - SCOPUS:84862147656

SN - 1053-4296

VL - 22

SP - 187

EP - 193

JO - Seminars in Radiation Oncology

JF - Seminars in Radiation Oncology

IS - 3

ER -

Biology of Human Papillomavirus-Related Oropharyngeal Cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this