Biology of Human Papillomavirus Infection and Immune Therapy for HPV-Related Head and Neck Cancers

Simon R. Best; Kevin J. Niparko; Sara I. Pai

doi:10.1016/j.otc.2012.04.005

Biology of Human Papillomavirus Infection and Immune Therapy for HPV-Related Head and Neck Cancers

Simon R. Best, Kevin J. Niparko, Sara I. Pai

School of Medicine

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

This article outlines the biology of human papillomavirus (HPV) infection of human mucosa and the cellular pathways that are altered through viral infection. The article provides a conceptual framework with which to understand the 2 major immunologic strategies to address HPV-related diseases: (1) prevention of primary HPV infection through the use of prophylactic vaccines and (2) treatment of established infection and diseases through therapeutic vaccines. Nonimmunologic therapy that targets cellular dysregulation induced by HPV infection is also discussed. The challenges in actualizing these conceptually attractive therapies on both a societal and biological level are examined.

Original language	English (US)
Pages (from-to)	807-822
Number of pages	16
Journal	Otolaryngologic Clinics of North America
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.otc.2012.04.005
State	Published - Aug 2012

Keywords

HPV-head and neck cancer
Immunotherapy
Oropharyngeal cancer
Vaccines

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.otc.2012.04.005

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title = "Biology of Human Papillomavirus Infection and Immune Therapy for HPV-Related Head and Neck Cancers",

abstract = "This article outlines the biology of human papillomavirus (HPV) infection of human mucosa and the cellular pathways that are altered through viral infection. The article provides a conceptual framework with which to understand the 2 major immunologic strategies to address HPV-related diseases: (1) prevention of primary HPV infection through the use of prophylactic vaccines and (2) treatment of established infection and diseases through therapeutic vaccines. Nonimmunologic therapy that targets cellular dysregulation induced by HPV infection is also discussed. The challenges in actualizing these conceptually attractive therapies on both a societal and biological level are examined.",

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AU - Best, Simon R.

AU - Niparko, Kevin J.

AU - Pai, Sara I.

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N2 - This article outlines the biology of human papillomavirus (HPV) infection of human mucosa and the cellular pathways that are altered through viral infection. The article provides a conceptual framework with which to understand the 2 major immunologic strategies to address HPV-related diseases: (1) prevention of primary HPV infection through the use of prophylactic vaccines and (2) treatment of established infection and diseases through therapeutic vaccines. Nonimmunologic therapy that targets cellular dysregulation induced by HPV infection is also discussed. The challenges in actualizing these conceptually attractive therapies on both a societal and biological level are examined.

AB - This article outlines the biology of human papillomavirus (HPV) infection of human mucosa and the cellular pathways that are altered through viral infection. The article provides a conceptual framework with which to understand the 2 major immunologic strategies to address HPV-related diseases: (1) prevention of primary HPV infection through the use of prophylactic vaccines and (2) treatment of established infection and diseases through therapeutic vaccines. Nonimmunologic therapy that targets cellular dysregulation induced by HPV infection is also discussed. The challenges in actualizing these conceptually attractive therapies on both a societal and biological level are examined.

KW - HPV-head and neck cancer

KW - Immunotherapy

KW - Oropharyngeal cancer

KW - Vaccines

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AN - SCOPUS:84863869305

SN - 0030-6665

VL - 45

SP - 807

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JO - Otolaryngologic Clinics of North America

JF - Otolaryngologic Clinics of North America

IS - 4

ER -

Biology of Human Papillomavirus Infection and Immune Therapy for HPV-Related Head and Neck Cancers

Abstract

Keywords

ASJC Scopus subject areas

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