Biologics in Acute Burn Injury

Samuel Kogan, Jordan Halsey, Richard L. Agag

Research output: Contribution to journalArticlepeer-review

Abstract

There have been significant advances in the care of burns over the past decade. As a result of the improved survival of burn patients, attention has shifted to the optimized management of their wounds. Traditionally, autografts have been described as the gold standard treatment in cases of deep second- and third-degree burn wounds; however, they are limited especially in large surface area burns. As such, advancements have been made in the development of biologic dressings, which attempt to mimic the function of the lost epidermis and/or dermis. The ideal biologic dressing is nontoxic, lacks antigenicity, is immunologically compatible, and is sterile. Additionally, easy storage conditions, long shelf lives, and reasonable costs are key determinants of whether biologic dressings may truly be widely used in the clinical setting. Biologic dressings serve an important role as skin substitutes in the setting of acute burn injury. This review aims to summarize the multitude of available biologic dressings and their applications. Methods The PubMed and Google Scholar databases were searched for the following terms either alone or in combination: "burn injury," "biologic membrane," "skin substitutes," "biosynthetic dressings," and "acellular membrane."

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalAnnals of plastic surgery
Volume83
Issue number1
DOIs
StatePublished - Jul 1 2019
Externally publishedYes

Keywords

  • acellular dermal matrix
  • acute burn injury
  • biologics
  • biosynthetic dressings
  • cultured epidermal autografts

ASJC Scopus subject areas

  • Surgery

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