Biological sex impacts COVID-19 outcomes

Sabra L. Klein; Santosh Dhakal; Rebecca L. Ursin; Sharvari Deshpande; Kathryn Sandberg; Franck Mauvais-Jarvis

doi:10.1371/journal.ppat.1008570

Biological sex impacts COVID-19 outcomes

Sabra L. Klein, Santosh Dhakal, Rebecca L. Ursin, Sharvari Deshpande, Kathryn Sandberg, Franck Mauvais-Jarvis

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.

Original language	English (US)
Article number	e1008570
Journal	PLoS pathogens
Volume	16
Issue number	6
DOIs	https://doi.org/10.1371/journal.ppat.1008570
State	Published - Jun 2020

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Molecular Biology
Genetics
Virology

Access to Document

10.1371/journal.ppat.1008570

Cite this

@article{e992dbddedc54158b066415c3b042b1d,

title = "Biological sex impacts COVID-19 outcomes",

abstract = "The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.",

author = "Klein, {Sabra L.} and Santosh Dhakal and Ursin, {Rebecca L.} and Sharvari Deshpande and Kathryn Sandberg and Franck Mauvais-Jarvis",

note = "Publisher Copyright: Copyright: {\textcopyright} 2020 Klein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2020",

month = jun,

doi = "10.1371/journal.ppat.1008570",

language = "English (US)",

volume = "16",

journal = "PLoS pathogens",

issn = "1553-7366",

publisher = "Public Library of Science",

number = "6",

}

TY - JOUR

T1 - Biological sex impacts COVID-19 outcomes

AU - Klein, Sabra L.

AU - Dhakal, Santosh

AU - Ursin, Rebecca L.

AU - Deshpande, Sharvari

AU - Sandberg, Kathryn

AU - Mauvais-Jarvis, Franck

N1 - Publisher Copyright: Copyright: © 2020 Klein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2020/6

Y1 - 2020/6

N2 - The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.

AB - The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.

UR - http://www.scopus.com/inward/record.url?scp=85086928851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85086928851&partnerID=8YFLogxK

U2 - 10.1371/journal.ppat.1008570

DO - 10.1371/journal.ppat.1008570

M3 - Article

C2 - 32569293

AN - SCOPUS:85086928851

SN - 1553-7366

VL - 16

JO - PLoS pathogens

JF - PLoS pathogens

IS - 6

M1 - e1008570

ER -

Biological sex impacts COVID-19 outcomes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this