Biological response to common surface bearings used in orthopaedics.

Guillaume Mabilleau, Hemant Pandit, Riyaz H. Jinnah, Afsie Sabokbar

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Wear particles are the most important cause of aseptic loosening of orthopaedic devices. To reduce the amount of particles generated from the conventional metal-on-polyethylene system, alternative bearings have been introduced. However, there are some concerns about so-called "adverse reactions" to these bearing surfaces. Despite an apparent longevity, metal particles and metal ions released from the prosthesis can induce a series of adverse reactions. The purpose of this review is to provide the readers an up-to-date overview of the literature on the biological responses to different bearing surfaces with particular reference to metal-on-metal bearings and the local and systemic effect of metal ions.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalJournal of surgical orthopaedic advances
Issue number1
StatePublished - 2008

ASJC Scopus subject areas

  • Medicine(all)


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