Biological response of chondrocytes to hydrogels

J. H. Elisseeff, A. Lee, H. K. Kleinman, Y. Yamada

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Primary bovine chondrocytes were encapsulated in alginate and alginate combined with cartilage matrix extract, Cartrigel, for the purpose of cartilage tissue engineering. The cell constructs were incubated in vitro and gene expression of cartilage-specific extracellular matrix molecules was quantitated and localized with in situ hybridization with a decrease in expression observed in the alginate-Cartrigel constructs. Further understanding of cell response to scaffolds will allow rational design and development of hydrogels for cartilage tissue engineering.

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalAnnals of the New York Academy of Sciences
StatePublished - 2002


  • Bioscaffolds
  • Cartilage replacement
  • Chondrocytes
  • Hydrogels

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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