Biological response of chondrocytes to hydrogels

J. H. Elisseeff; A. Lee; H. K. Kleinman; Y. Yamada

doi:10.1111/j.1749-6632.2002.tb03062.x

Biological response of chondrocytes to hydrogels

J. H. Elisseeff, A. Lee, H. K. Kleinman, Y. Yamada

School of Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Primary bovine chondrocytes were encapsulated in alginate and alginate combined with cartilage matrix extract, Cartrigel, for the purpose of cartilage tissue engineering. The cell constructs were incubated in vitro and gene expression of cartilage-specific extracellular matrix molecules was quantitated and localized with in situ hybridization with a decrease in expression observed in the alginate-Cartrigel constructs. Further understanding of cell response to scaffolds will allow rational design and development of hydrogels for cartilage tissue engineering.

Original language	English (US)
Pages (from-to)	118-122
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	961
DOIs	https://doi.org/10.1111/j.1749-6632.2002.tb03062.x
State	Published - 2002

Keywords

Bioscaffolds
Cartilage replacement
Chondrocytes
Hydrogels

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/j.1749-6632.2002.tb03062.x

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AU - Lee, A.

AU - Kleinman, H. K.

AU - Yamada, Y.

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AB - Primary bovine chondrocytes were encapsulated in alginate and alginate combined with cartilage matrix extract, Cartrigel, for the purpose of cartilage tissue engineering. The cell constructs were incubated in vitro and gene expression of cartilage-specific extracellular matrix molecules was quantitated and localized with in situ hybridization with a decrease in expression observed in the alginate-Cartrigel constructs. Further understanding of cell response to scaffolds will allow rational design and development of hydrogels for cartilage tissue engineering.

KW - Bioscaffolds

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KW - Chondrocytes

KW - Hydrogels

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Biological response of chondrocytes to hydrogels

Abstract

Keywords

ASJC Scopus subject areas

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