Biological basis of depression in adults with diabetes

Shivam Champaneri, Gary S. Wand, Saurabh S. Malhotra, Sarah S. Casagrande, Sherita Hill Golden

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.

Original languageEnglish (US)
Pages (from-to)396-405
Number of pages10
JournalCurrent diabetes reports
Issue number6
StatePublished - Dec 2010


  • Adipocytokines
  • Awakening cortisol
  • C-reactive protein (CRP)
  • Catecholamines
  • Cortisol
  • Cortisol awakening response
  • Cytokines
  • Depression
  • Diabetes
  • Diurnal cortisol
  • Heart rate variability
  • Hypothalamic-pituitary-adrenal (HPA) axis
  • Inflammation
  • Inflammatory markers
  • Insulin resistance
  • Interleukin-6 (IL-6)
  • Metabolic syndrome
  • Obesity
  • Sympathetic nervous system
  • Type 2 diabetes
  • Visceral fat

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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