Biological approaches to the treatment of cancer

S. H. Goey, J. Wagstaff, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Since the turn of the century, attempts have been made to modify the patient's host defense mechanisms to his tumour. Despite occasional anecdotal reports of antitumour activity of such an approach, larger studies have failed to demonstrate convincing efficacy for these non-specific immunostimulants. During the last 5 years, tremendous advances have been made in molecular biology which, for the first time, has allowed the production of biological molecules in very pure form. For the first time, research both in the laboratory and the clinic using these reagents is beginning to unravel the relationship between the immune system and the tumour. In this article we will review the current status of laboratory and clinical research with biological response modifiers and attempt to suggest ways in which new, novel and hopefully more effective therapies for cancer may be developed. Neth J Med 1988,33:41-47.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalNetherlands Journal of Medicine
Issue number1
StatePublished - Jul 1988
Externally publishedYes


  • Biological response modifier
  • Immunotherapy

ASJC Scopus subject areas

  • General Medicine


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