@inbook{b492b21cbf7c4d8ba9d50390dbca1c7f,
title = "BIOINSPIRED NANOTOPOGRAPHICALLY-DEFINED CELL CULTURE MODELS",
abstract = "In vivo, cells are surrounded by an extracellular matrix which provides the cell with topographical cues on the nanoscale. To more closely mimic the in vivo environment, nanopatterned biomaterials have been used in cell culture. Through experimental research it has been shown that the nanotopography of the substrate greatly affects cell behavior, and that the specifics of the nanotopographically-defined substrate additionally influence stem cell differentiation. In this chapter, we discuss fabrication techniques for creating nanotopographically-defined biomaterials. We also review the advantages and constraints of each method as applied to stem cell culture and engineering. Additionally, we highlight results from studies of stem cells performed using both two- and three-dimensional nanotopographically defined substrates. Finally, we consider the potential applications of these technologies, both in medicine and research, and we examine the current challenges that must be addressed to advance this field.",
author = "Julie Antetomaso and Alex Jiao and Krystal Gauthier-Bell and Kim, {Deok Ho}",
note = "Publisher Copyright: {\textcopyright} 2014 World Scientific Publishing Co. Pte. Ltd.",
year = "2014",
doi = "10.1142/9789814354936_0042",
language = "English (US)",
series = "World Scientific Series in Nanoscience and Nanotechnology",
publisher = "World Scientific",
number = "3",
pages = "1149--1176",
editor = "Esmaiel Jabbari and Deok-Ho Kim and Lee, {Luke P.} and Amir Ghaemmaghami and Ali Khademhosseini and Ali Khademhosseini",
booktitle = "World Scientific Series in Nanoscience and Nanotechnology",
address = "United States",
edition = "3",
}