BIOINSPIRED NANOTOPOGRAPHICALLY-DEFINED CELL CULTURE MODELS

Julie Antetomaso, Alex Jiao, Krystal Gauthier-Bell, Deok Ho Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In vivo, cells are surrounded by an extracellular matrix which provides the cell with topographical cues on the nanoscale. To more closely mimic the in vivo environment, nanopatterned biomaterials have been used in cell culture. Through experimental research it has been shown that the nanotopography of the substrate greatly affects cell behavior, and that the specifics of the nanotopographically-defined substrate additionally influence stem cell differentiation. In this chapter, we discuss fabrication techniques for creating nanotopographically-defined biomaterials. We also review the advantages and constraints of each method as applied to stem cell culture and engineering. Additionally, we highlight results from studies of stem cells performed using both two- and three-dimensional nanotopographically defined substrates. Finally, we consider the potential applications of these technologies, both in medicine and research, and we examine the current challenges that must be addressed to advance this field.

Original languageEnglish (US)
Title of host publicationWorld Scientific Series in Nanoscience and Nanotechnology
EditorsEsmaiel Jabbari, Deok-Ho Kim, Luke P. Lee, Amir Ghaemmaghami, Ali Khademhosseini, Ali Khademhosseini
PublisherWorld Scientific
Pages1149-1176
Number of pages28
Edition3
DOIs
StatePublished - 2014
Externally publishedYes

Publication series

NameWorld Scientific Series in Nanoscience and Nanotechnology
Number3
Volume9
ISSN (Print)2301-301X
ISSN (Electronic)2335-6693

ASJC Scopus subject areas

  • Chemistry (miscellaneous)

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