Biogenesis of synaptic vesicles

R. B. Kelly; F. Bonzelius; A. Cleves; L. Clift-O'Grady; E. Grote; G. Herman

doi:10.1242/jcs.1993.supplement_17.12

Biogenesis of synaptic vesicles

R. B. Kelly, F. Bonzelius, A. Cleves, L. Clift-O'Grady, E. Grote, G. Herman

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	Journal of cell science
Volume	106
Issue number	SUPPL. 17
DOIs	https://doi.org/10.1242/jcs.1993.supplement_17.12
State	Published - 1993
Externally published	Yes

Keywords

Endosome
PC12 cells
Synaptic vesicles
Synaptobrevin
VAMP

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1242/jcs.1993.supplement_17.12

Cite this

@article{23322a35d07f4e69a8564be327f88684,

title = "Biogenesis of synaptic vesicles",

abstract = "The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.",

keywords = "Endosome, PC12 cells, Synaptic vesicles, Synaptobrevin, VAMP",

author = "Kelly, {R. B.} and F. Bonzelius and A. Cleves and L. Clift-O'Grady and E. Grote and G. Herman",

year = "1993",

doi = "10.1242/jcs.1993.supplement_17.12",

language = "English (US)",

volume = "106",

pages = "81--83",

journal = "The Quarterly journal of microscopical science",

issn = "0021-9533",

publisher = "Company of Biologists Ltd",

number = "SUPPL. 17",

}

TY - JOUR

T1 - Biogenesis of synaptic vesicles

AU - Kelly, R. B.

AU - Bonzelius, F.

AU - Cleves, A.

AU - Clift-O'Grady, L.

AU - Grote, E.

AU - Herman, G.

PY - 1993

Y1 - 1993

N2 - The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.

AB - The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.

KW - Endosome

KW - PC12 cells

KW - Synaptic vesicles

KW - Synaptobrevin

KW - VAMP

UR - http://www.scopus.com/inward/record.url?scp=0027769076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027769076&partnerID=8YFLogxK

U2 - 10.1242/jcs.1993.supplement_17.12

DO - 10.1242/jcs.1993.supplement_17.12

M3 - Article

C2 - 7511619

AN - SCOPUS:0027769076

SN - 0021-9533

VL - 106

SP - 81

EP - 83

JO - The Quarterly journal of microscopical science

JF - The Quarterly journal of microscopical science

IS - SUPPL. 17

ER -

Biogenesis of synaptic vesicles

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this