Abstract
This chapter introduces innovative organ-on-chip platforms for chemical assay and toxicity testing that measures the physiological properties of live, engineered muscular tissue samples. The advantages of using such engineered tissues for drug screening compared to more conventional cell-based assays are discussed. Specifically, this chapter will outline recent developments and applications of cardiac and skeletal muscle organ-on-chip systems. Recent advances in micro- and nanofabrication techniques, along with their biological applications with regard to organ-on-chips, are also reviewed in this chapter.
Original language | English (US) |
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Title of host publication | Biomedical Engineering |
Subtitle of host publication | Frontier Research and Converging Technologies |
Publisher | Springer International Publishing |
Pages | 199-208 |
Number of pages | 10 |
Volume | 9 |
ISBN (Electronic) | 9783319218137 |
ISBN (Print) | 9783319218120 |
DOIs | |
State | Published - Jul 23 2015 |
Externally published | Yes |
Keywords
- Heart-on-chip
- Micro/nanofabrication
- Muscle-on-chip
- Organ-on-chip
ASJC Scopus subject areas
- General Engineering
- General Medicine
- General Neuroscience
- General Biochemistry, Genetics and Molecular Biology