Abstract
Bridging IgE receptors of rat mast cells and basophilic leukemia cells initiates a series of biochemical events to lead histamine release: increased phospholipid methylation is followed by Ca2+ influx and activation of phospholipase(s). This cascade mechanism of phospholipid metabolism is supported by the experiments with specific inhibitors of each step and variants of rat basophilic leukemia cells.
Original language | English (US) |
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Pages (from-to) | 43-45 |
Number of pages | 3 |
Journal | Advances in the Biosciences |
Volume | 33 |
Issue number | C |
State | Published - 1982 |
Externally published | Yes |
Keywords
- Ca channel
- Phospholipid methylation
- arachidonic acid
- mutants
- phospholipases