Biochemical Epidemiology of Cervical Neoplasia: Measuring Cigarette Smoke Constituents in the Cervix

Mark H. Schiffman; Nancy J. Haley; James S. Felton; A. W. Andrews; Richard A. Kaslow; Wayne D. Lancaster; Robert J. Kurman; Louise A. Brinton; Linda B. Lannom; Dietrich Hoffmann

Biochemical Epidemiology of Cervical Neoplasia: Measuring Cigarette Smoke Constituents in the Cervix

Mark H. Schiffman, Nancy J. Haley, James S. Felton, A. W. Andrews, Richard A. Kaslow, Wayne D. Lancaster, Robert J. Kurman, Louise A. Brinton, Linda B. Lannom, Dietrich Hoffmann

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

In preparation for an epidemiological investigation of cigarette smoking and cervical neoplasia, we studied methods of measuring cervical exposure to tobacco smoke. The measurement of cotinine in cervical flushes by radioimmunoassay proved to be highly accurate in distinguishing smokers from nonsmokers, achieving 100% sensitivity and 97% specificity. In most subjects, quantitative levels of cervical cotinine and nicotine mirrored recent smoking intensity. Some of the apparent exceptions may have resulted from metabolic/secretory traits of the subjects. If so, the biochemical measurement of smoke constituents in the cervix might prove more valuable for epidemiological studies of cervical neoplasia than data on current smoking behavior collected by interview.

Original language	English (US)
Pages (from-to)	3886-3888
Number of pages	3
Journal	Cancer Research
Volume	47
Issue number	14
State	Published - Jul 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Biochemical Epidemiology of Cervical Neoplasia: Measuring Cigarette Smoke Constituents in the Cervix",

abstract = "In preparation for an epidemiological investigation of cigarette smoking and cervical neoplasia, we studied methods of measuring cervical exposure to tobacco smoke. The measurement of cotinine in cervical flushes by radioimmunoassay proved to be highly accurate in distinguishing smokers from nonsmokers, achieving 100% sensitivity and 97% specificity. In most subjects, quantitative levels of cervical cotinine and nicotine mirrored recent smoking intensity. Some of the apparent exceptions may have resulted from metabolic/secretory traits of the subjects. If so, the biochemical measurement of smoke constituents in the cervix might prove more valuable for epidemiological studies of cervical neoplasia than data on current smoking behavior collected by interview.",

author = "Schiffman, {Mark H.} and Haley, {Nancy J.} and Felton, {James S.} and Andrews, {A. W.} and Kaslow, {Richard A.} and Lancaster, {Wayne D.} and Kurman, {Robert J.} and Brinton, {Louise A.} and Lannom, {Linda B.} and Dietrich Hoffmann",

year = "1987",

month = jul,

language = "English (US)",

volume = "47",

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journal = "Cancer Research",

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publisher = "American Association for Cancer Research Inc.",

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AU - Schiffman, Mark H.

AU - Haley, Nancy J.

AU - Felton, James S.

AU - Andrews, A. W.

AU - Kaslow, Richard A.

AU - Lancaster, Wayne D.

AU - Kurman, Robert J.

AU - Brinton, Louise A.

AU - Lannom, Linda B.

AU - Hoffmann, Dietrich

PY - 1987/7

Y1 - 1987/7

N2 - In preparation for an epidemiological investigation of cigarette smoking and cervical neoplasia, we studied methods of measuring cervical exposure to tobacco smoke. The measurement of cotinine in cervical flushes by radioimmunoassay proved to be highly accurate in distinguishing smokers from nonsmokers, achieving 100% sensitivity and 97% specificity. In most subjects, quantitative levels of cervical cotinine and nicotine mirrored recent smoking intensity. Some of the apparent exceptions may have resulted from metabolic/secretory traits of the subjects. If so, the biochemical measurement of smoke constituents in the cervix might prove more valuable for epidemiological studies of cervical neoplasia than data on current smoking behavior collected by interview.

AB - In preparation for an epidemiological investigation of cigarette smoking and cervical neoplasia, we studied methods of measuring cervical exposure to tobacco smoke. The measurement of cotinine in cervical flushes by radioimmunoassay proved to be highly accurate in distinguishing smokers from nonsmokers, achieving 100% sensitivity and 97% specificity. In most subjects, quantitative levels of cervical cotinine and nicotine mirrored recent smoking intensity. Some of the apparent exceptions may have resulted from metabolic/secretory traits of the subjects. If so, the biochemical measurement of smoke constituents in the cervix might prove more valuable for epidemiological studies of cervical neoplasia than data on current smoking behavior collected by interview.

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SN - 0008-5472

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Biochemical Epidemiology of Cervical Neoplasia: Measuring Cigarette Smoke Constituents in the Cervix

Abstract

ASJC Scopus subject areas

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