Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats

J. E. Clements; O. Narayan; L. C. Cork

doi:10.1099/0022-1317-50-2-423

Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats

J. E. Clements, O. Narayan, L. C. Cork

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Goat leukoencephalitis-arthritis virus (GLV) has the density of a retrovirus in sucrose and contains an endogenous RNA-dependent DNA polymerase (reverse transcriptase). The virion reverse transcriptase virus the synthetic RNA template poly(rA).(dT)₁₂ but not the synthetic DNA template poly(dA).(dT)₁₂. A high mol. wt. RNA similar in size to visna virs RNA was isolated from ³H-uridine-labelled virions. The major structural protein of GLV has the same mol. wt. as that of visna virus. From these data the GLV appears to be a retrovirus.

Original language	English (US)
Pages (from-to)	423-427
Number of pages	5
Journal	Journal of General Virology
Volume	50
Issue number	2
DOIs	https://doi.org/10.1099/0022-1317-50-2-423
State	Published - 1980

ASJC Scopus subject areas

Virology

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10.1099/0022-1317-50-2-423

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abstract = "Goat leukoencephalitis-arthritis virus (GLV) has the density of a retrovirus in sucrose and contains an endogenous RNA-dependent DNA polymerase (reverse transcriptase). The virion reverse transcriptase virus the synthetic RNA template poly(rA).(dT)12 but not the synthetic DNA template poly(dA).(dT)12. A high mol. wt. RNA similar in size to visna virs RNA was isolated from 3H-uridine-labelled virions. The major structural protein of GLV has the same mol. wt. as that of visna virus. From these data the GLV appears to be a retrovirus.",

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AU - Narayan, O.

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AB - Goat leukoencephalitis-arthritis virus (GLV) has the density of a retrovirus in sucrose and contains an endogenous RNA-dependent DNA polymerase (reverse transcriptase). The virion reverse transcriptase virus the synthetic RNA template poly(rA).(dT)12 but not the synthetic DNA template poly(dA).(dT)12. A high mol. wt. RNA similar in size to visna virs RNA was isolated from 3H-uridine-labelled virions. The major structural protein of GLV has the same mol. wt. as that of visna virus. From these data the GLV appears to be a retrovirus.

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Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats

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