Bioassay for SF 86-327, a new antifungal agent

V. L. Kan; D. K. Henderson; J. E. Bennett

doi:10.1128/AAC.30.4.628

Bioassay for SF 86-327, a new antifungal agent

V. L. Kan, D. K. Henderson, J. E. Bennett

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.

Original language	English (US)
Pages (from-to)	628-629
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	30
Issue number	4
DOIs	https://doi.org/10.1128/AAC.30.4.628
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.30.4.628

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title = "Bioassay for SF 86-327, a new antifungal agent",

abstract = "A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.",

author = "Kan, {V. L.} and Henderson, {D. K.} and Bennett, {J. E.}",

year = "1986",

doi = "10.1128/AAC.30.4.628",

language = "English (US)",

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AU - Henderson, D. K.

AU - Bennett, J. E.

PY - 1986

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AB - A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

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Bioassay for SF 86-327, a new antifungal agent

Abstract

ASJC Scopus subject areas

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