Bilateral Sequential Dacryocystitis in a Patient with Graft-Versus-Host Disease

Ashley Campbell, Frederick A. Jakobiec, Alia Rashid, Reza Dana, Michael K. Yoon

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A 29-year-old woman with a history of 2 bone marrow transplants for acute myelogenous leukemia developed bilateral sequential dacryocystitis in the context of known ocular graft-versus-host disease. With each infection, the patient underwent uneventful dacryocystorhinostomy. Postoperatively, she developed severe dry eye disease requiring replacement of punctal plugs and use of a prosthetic replacement of the ocular surface ecosystem lens. Histopathologic and immunohistochemical examination of the lacrimal sac showed a dense diffuse nonfollicular lymphocytic subepithelial infiltrate in the lacrimal sac that contained moderately more T-cells than B-cells. This is the first report of acute dacryocystitis associated with graft-versus-host disease. The authors caution that similar patients may develop worsening of ocular surface dryness due to restoration of normal lacrimal outflow.

Original languageEnglish (US)
Pages (from-to)e89-e92
JournalOphthalmic Plastic and Reconstructive Surgery
Issue number4
StatePublished - Aug 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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