Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms

Azam Jamshidian; Vahid Shaygannejad; Abbasali Pourazar; Sayyed Hamid Zarkesh-Esfahani; Marjan Gharagozloo

doi:10.1016/j.jneuroim.2013.06.007

Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms

Azam Jamshidian, Vahid Shaygannejad, Abbasali Pourazar, Sayyed Hamid Zarkesh-Esfahani, Marjan Gharagozloo

Research output: Contribution to journal › Article › peer-review

Abstract

The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease.

Original language	English (US)
Pages (from-to)	106-112
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	262
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.06.007
State	Published - 2013
Externally published	Yes

Keywords

Multiple sclerosis
Th17
Treg

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2013.06.007

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title = "Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms",

abstract = "The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease.",

keywords = "Multiple sclerosis, Th17, Treg",

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AU - Jamshidian, Azam

AU - Shaygannejad, Vahid

AU - Pourazar, Abbasali

AU - Zarkesh-Esfahani, Sayyed Hamid

AU - Gharagozloo, Marjan

PY - 2013

Y1 - 2013

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AB - The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease.

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Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms

Abstract

Keywords

ASJC Scopus subject areas

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