@inproceedings{b8d06d58ac934c2c81f5b00110d6dd5d,
title = "Bi-directional Synthesis of Pre- and Post-contrast MRI via Guided Feature Disentanglement",
abstract = "Magnetic resonance imaging (MRI) with gadolinium contrast is widely used for tissue enhancement and better identification of active lesions and tumors. Recent studies have shown that gadolinium deposition can accumulate in tissues including the brain, which raises safety concerns. Prior works have tried to synthesize post-contrast T1-weighted MRIs from pre-contrast MRIs to avoid the use of gadolinium. However, contrast and image representations are often entangled during the synthesis process, resulting in synthetic post-contrast MRIs with undesirable contrast enhancements. Moreover, the synthesis of pre-contrast MRIs from post-contrast MRIs which can be useful for volumetric analysis is rarely investigated in the literature. To tackle pre- and post- contrast MRI synthesis, we propose a BI-directional Contrast Enhancement Prediction and Synthesis (BICEPS) network that enables disentanglement of contrast and image representations via a bi-directional image-to-image translation (I2I) model. Our proposed model can perform both pre-to-post and post-to-pre contrast synthesis, and provides an interpretable synthesis process by predicting contrast enhancement maps from the learned contrast embedding. Extensive experiments on a multiple sclerosis dataset demonstrate the feasibility of applying our bidirectional synthesis and show that BICEPS outperforms current methods.",
keywords = "Contrast Enhancement, Feature Disentanglement, Multi-modal MRI Synthesis, Multiple Sclerosis",
author = "Yuan Xue and Dewey, {Blake E.} and Lianrui Zuo and Shuo Han and Aaron Carass and Peiyu Duan and Remedios, {Samuel W.} and Pham, {Dzung L.} and Shiv Saidha and Calabresi, {Peter A.} and Prince, {Jerry L.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.; 7th International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2022, held in conjunction with 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022 ; Conference date: 18-09-2022 Through 18-09-2022",
year = "2022",
doi = "10.1007/978-3-031-16980-9_6",
language = "English (US)",
isbn = "9783031169793",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "55--65",
editor = "Can Zhao and David Svoboda and Wolterink, {Jelmer M.} and Maria Escobar",
booktitle = "Simulation and Synthesis in Medical Imaging - 7th International Workshop, SASHIMI 2022, Held in Conjunction with MICCAI 2022, Proceedings",
address = "Germany",
}