Beyond the scalpel: Targeting hedgehog in skin cancer prevention

Charles M. Rudin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This perspective places the article by Tang et al. in this issue of the journal (beginning on page 25) in the context of recent work defining the hedgehog signaling pathway as a central etiologic factor and as a therapeutic target in basal cell cancer. Tang et al. show that inhibition of cyclooxygenase activity, either genetically (in a relevant mouse model) or pharmacologically (in the mouse and in patients highly predisposed to develop basal cell skin cancers), may suppress basal cell carcinogenesis. This new study of cyclooxygenase inhibition, together with recent data on the efficacy of hedgehog pathway inhibition, offers new hope for patients at a high risk for basal cell cancer.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalCancer Prevention Research
Issue number1
StatePublished - Jan 2010

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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