Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders

Hui Chen, Annie Y. Chan, Donald U. Stone, Nawajes A. Mandal

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Sphingolipids are a ubiquitous membrane lipid present in every cell and found most abundantly in neural tissues. Disorders such as Tay-Sachs or Niemann-Pick disease are the most familiar examples of dysfunction in sphingolipid metabolism and are typically associated with neurodegeneration and ocular findings such as blindness. More recently, the role of bioactive sphingolipids has been established in a multitude of cellular events, including cell survival, growth, senescence and apoptosis, inflammation, and neovascularization. We discuss our current knowledge and understanding of sphingolipid metabolism and signaling in the pathogenesis of ocular diseases.

Original languageEnglish (US)
Pages (from-to)64-76
Number of pages13
JournalSurvey of ophthalmology
Volume59
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Ceramide
  • FTY720
  • Retina
  • Retinal degenerations
  • Sphingolipid
  • Sphingosine
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

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