Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study

Majid Fotuhi; Peter P. Zandi; Kathleen M. Hayden; Ara S. Khachaturian; Christine A. Szekely; Heidi Wengreen; Ronald G. Munger; Maria C. Norton; Jo Ann T. Tschanz; Constantine G. Lyketsos; John C.S. Breitner; Kathleen Welsh-Bohmer

doi:10.1016/j.jalz.2008.01.004

Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study

Majid Fotuhi, Peter P. Zandi, Kathleen M. Hayden, Ara S. Khachaturian, Christine A. Szekely, Heidi Wengreen, Ronald G. Munger, Maria C. Norton, Jo Ann T. Tschanz, Constantine G. Lyketsos, John C.S. Breitner, Kathleen Welsh-Bohmer

School of Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE ε4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE ε4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.

Original language	English (US)
Pages (from-to)	223-227
Number of pages	5
Journal	Alzheimer's and Dementia
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.jalz.2008.01.004
State	Published - May 2008

Keywords

Antioxidant vitamins
Cognitive performance
Dementia prevention
NSAIDs
Random effect model

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

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10.1016/j.jalz.2008.01.004

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Fotuhi, M., Zandi, P. P., Hayden, K. M., Khachaturian, A. S., Szekely, C. A., Wengreen, H., Munger, R. G., Norton, M. C., Tschanz, J. A. T., Lyketsos, C. G., Breitner, J. C. S., & Welsh-Bohmer, K. (2008). Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study. Alzheimer's and Dementia, 4(3), 223-227. https://doi.org/10.1016/j.jalz.2008.01.004

Fotuhi, M, Zandi, PP, Hayden, KM, Khachaturian, AS, Szekely, CA, Wengreen, H, Munger, RG, Norton, MC, Tschanz, JAT, Lyketsos, CG, Breitner, JCS & Welsh-Bohmer, K 2008, 'Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study', Alzheimer's and Dementia, vol. 4, no. 3, pp. 223-227. https://doi.org/10.1016/j.jalz.2008.01.004

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title = "Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study",

abstract = "Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE ε4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE ε4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.",

keywords = "Antioxidant vitamins, Cognitive performance, Dementia prevention, NSAIDs, Random effect model",

author = "Majid Fotuhi and Zandi, {Peter P.} and Hayden, {Kathleen M.} and Khachaturian, {Ara S.} and Szekely, {Christine A.} and Heidi Wengreen and Munger, {Ronald G.} and Norton, {Maria C.} and Tschanz, {Jo Ann T.} and Lyketsos, {Constantine G.} and Breitner, {John C.S.} and Kathleen Welsh-Bohmer",

note = "Funding Information: This research was supported by grants R01-AG-11380 from the National Institute of Health, Bethesda, MD, T32-MH-14592 from the National Institute of Mental Health, Bethesda, MD (Dr Zandi), and T32-AG-00029 from the National Institute on Aging, Bethesda, MD (Dr Hayden). We are grateful to the neurogenetics laboratory of the Bryan Alzheimer's Disease Research Center at Duke University for the APOE genotyping and to all members of the Cache County Study.",

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doi = "10.1016/j.jalz.2008.01.004",

language = "English (US)",

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T2 - The Cache County Study

AU - Fotuhi, Majid

AU - Zandi, Peter P.

AU - Hayden, Kathleen M.

AU - Khachaturian, Ara S.

AU - Szekely, Christine A.

AU - Wengreen, Heidi

AU - Munger, Ronald G.

AU - Norton, Maria C.

AU - Tschanz, Jo Ann T.

AU - Lyketsos, Constantine G.

AU - Breitner, John C.S.

AU - Welsh-Bohmer, Kathleen

N1 - Funding Information: This research was supported by grants R01-AG-11380 from the National Institute of Health, Bethesda, MD, T32-MH-14592 from the National Institute of Mental Health, Bethesda, MD (Dr Zandi), and T32-AG-00029 from the National Institute on Aging, Bethesda, MD (Dr Hayden). We are grateful to the neurogenetics laboratory of the Bryan Alzheimer's Disease Research Center at Duke University for the APOE genotyping and to all members of the Cache County Study.

PY - 2008/5

Y1 - 2008/5

N2 - Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE ε4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE ε4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.

AB - Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE ε4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE ε4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.

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KW - Dementia prevention

KW - NSAIDs

KW - Random effect model

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Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study

Abstract

Keywords

ASJC Scopus subject areas

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