Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system

An L. Moens, Ronghua Yang, Vabren L. Watts, Lili A. Barouch

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


The presence of a third β-adrenergic receptor (β3-AR) in the cardiovascular system has challenged the classical paradigm of sympathetic regulation by β1- and β2-adrenergic receptors. While β3-AR's role in the cardiovascular system remains controversial, increasing evidence suggests that it serves as a "brake" in sympathetic overstimulation - it is activated at high catecholamine concentrations, producing a negative inotropic effect that antagonizes β1- and β2-AR activity. The anti-adrenergic effects induced by β3-AR were initially linked to nitric oxide (NO) release via endothelial NO synthase (eNOS), although more recently it has been shown under some conditions to increase NO production in the cardiovascular system via the other two NOS isoforms, namely inducible NOS (iNOS) and neuronal NOS (nNOS). We summarize recent findings regarding β3-AR effects on the cardiovascular system and explore its prospective as a therapeutic target, particularly focusing on its emerging role as an important mediator of NO signaling in the pathogenesis of cardiovascular disorders.

Original languageEnglish (US)
Pages (from-to)1088-1095
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Issue number6
StatePublished - Jun 2010


  • Beta 3 adrenergic receptor
  • Cardiovascular
  • Heart failure
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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