Jean Luc Fouilladieu, Jerome D'Enfert, Christian Conseiller, Robert Hausner, Theodore Pearlman, David Haskell, Eve Bargmann, Sidney M. Wolfe, David J. Greenblatt, Richard I. Shader

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


To the Editor: We were surprised to note that paradoxical effects of benzodiazepines are not mentioned by Greenblatt and colleagues (Aug. 11 and 18 issues).1 These adverse reactions, including hyperactivity and irritability, were first described, for chlordiazepoxide, by Ingram and Timbury.2 Since then, other paradoxical reactions, such as paradoxical excitement,3 hostile behavior,4 verbal and physical aggression,5 symptoms of delirium,6 rage reaction,7 increased anxiety or panic,8 and increased seizure frequency,3 have been reported. Several benzodiazepines, including chlordiazepoxide,2 diazepam,3,6 clonazepam,3 triazolam,5 lorazepam,6 clorazepate,7 temazepam,8 and clobazam9 have been associated with such reactions. Unlike common side effects (drowsiness and ataxia), which are related.

Original languageEnglish (US)
Pages (from-to)464-466
Number of pages3
JournalNew England Journal of Medicine
Issue number7
StatePublished - Feb 16 1984
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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