Abstract
Mesenchymal tumors of the breast demonstrate differentiation towards the non-epithelial components of the breast, including the vasculature, adipose tissue, smooth muscle, nerve sheath elements, and stromal myofibroblasts. The neoplasms can be benign or malignant and morphologically resemble their counterparts in other soft-tissue sites. The hamartomatous lesions are disorganized proliferations of the normal mesenchymal components admixed with the breast epithelial component. Here, we will review the features of mesenchymal tumors encountered on breast core needle biopsy, including the following diagnostic entities: lipoma, angiolipoma, hibernoma, leiomyoma, hamartoma, nodular mucinosis, myofibroblastoma, pseudoangiomatous stromal hyperplasia, fibromatosis, dermatofibroma, granular cell tumor, neurofibroma, schwannoma, and primary breast sarcoma (leiomyosarcoma, liposarcoma, fibrosarcoma, osteosarcoma, malignant peripheral nerve sheath tumor, undifferentiated pleomorphic sarcoma, and dermatofibrosarcoma protuberans). Vascular lesions of the breast will be discussed in a separate chapter.
Original language | English (US) |
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Title of host publication | A Comprehensive Guide to Core Needle Biopsies of the Breast, Second Edition |
Publisher | Springer International Publishing |
Pages | 691-736 |
Number of pages | 46 |
ISBN (Electronic) | 9783031055324 |
ISBN (Print) | 9783031055317 |
DOIs | |
State | Published - Jan 1 2022 |
Keywords
- Fibromatosis
- Granular cell tumor
- Hamartoma
- Lipoma
- Mesenchymal tumor
- Myofibroblastoma
- Nerve sheath tumor
- PASH
- Sarcoma
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology