Benign and Malignant Mesenchymal Tumors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mesenchymal tumors of the breast demonstrate differentiation towards the non-epithelial components of the breast, including the vasculature, adipose tissue, smooth muscle, nerve sheath elements, and stromal myofibroblasts. The neoplasms can be benign or malignant and morphologically resemble their counterparts in other soft-tissue sites. The hamartomatous lesions are disorganized proliferations of the normal mesenchymal components admixed with the breast epithelial component. Here, we will review the features of mesenchymal tumors encountered on breast core needle biopsy, including the following diagnostic entities: lipoma, angiolipoma, hibernoma, leiomyoma, hamartoma, nodular mucinosis, myofibroblastoma, pseudoangiomatous stromal hyperplasia, fibromatosis, dermatofibroma, granular cell tumor, neurofibroma, schwannoma, and primary breast sarcoma (leiomyosarcoma, liposarcoma, fibrosarcoma, osteosarcoma, malignant peripheral nerve sheath tumor, undifferentiated pleomorphic sarcoma, and dermatofibrosarcoma protuberans). Vascular lesions of the breast will be discussed in a separate chapter.

Original languageEnglish (US)
Title of host publicationA Comprehensive Guide to Core Needle Biopsies of the Breast, Second Edition
PublisherSpringer International Publishing
Pages691-736
Number of pages46
ISBN (Electronic)9783031055324
ISBN (Print)9783031055317
DOIs
StatePublished - Jan 1 2022

Keywords

  • Fibromatosis
  • Granular cell tumor
  • Hamartoma
  • Lipoma
  • Mesenchymal tumor
  • Myofibroblastoma
  • Nerve sheath tumor
  • PASH
  • Sarcoma

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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