TY - JOUR
T1 - Benefits of fatty fish on dementia risk are stronger for those without APOE ε4
AU - Huang, Tina L.
AU - Zandi, P. P.
AU - Tucker, K. L.
AU - Fitzpatrick, A. L.
AU - Kuller, L. H.
AU - Fried, L. P.
AU - Burke, G. L.
AU - Carlson, M. C.
N1 - Funding Information:
T.L.H. was supported by NIH grant T32-MH14592 and NIH/NIDDK grant T32 DK75610, a grant from the Charles A. King Trust, Bank of America, Co-Trustee (Boston, MA), and by the USDA Agricultural Research Service under contract no. 53-3K06-5-10. The research reported in this article was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, and N01 HC-15103 from the National Heart, Lung, and Blood Institute, and grant AG15928 from the National Institute on Aging.
PY - 2005/11/8
Y1 - 2005/11/8
N2 - Objective: To compare associations of lean fish vs fatty fish (tuna or other fish) intake with dementia, Alzheimer disease (AD), and vascular dementia (VaD) and in relation to APOE ε4 status in the Cardiovascular Health Cognition Study (CHCS). Methods: Fish intake was assessed by food frequency questionnaires. Incident dementia, AD, and VaD were determined through a series of cognitive tests, physician's assessment, and committee consensus. We used Cox proportional hazards regression to calculate hazard ratios of dementia, AD, and VaD with lean fried fish, fatty fish, or total fish intake, which were then stratified by the presence of APOE ε4. Results: Although consumption of lean fried fish had no protective effect, consumption of fatty fish more than twice per week was associated with a reduction in risk of dementia by 28% (95% CI: 0.51 to 1.02), and AD by 41% (95% CI: 0.36 to 0.95) in comparison to those who ate fish less than once per month. Stratification by APOE ε4 showed this effect to be selective to those without the ε4 allele. Adjustment by education and income attenuated the effect. Conclusion: In the Cardiovascular Health Cognition Study, consumption of fatty fish was associated with a reduced risk of dementia and Alzheimer disease for those without the APOE ε4 allele.
AB - Objective: To compare associations of lean fish vs fatty fish (tuna or other fish) intake with dementia, Alzheimer disease (AD), and vascular dementia (VaD) and in relation to APOE ε4 status in the Cardiovascular Health Cognition Study (CHCS). Methods: Fish intake was assessed by food frequency questionnaires. Incident dementia, AD, and VaD were determined through a series of cognitive tests, physician's assessment, and committee consensus. We used Cox proportional hazards regression to calculate hazard ratios of dementia, AD, and VaD with lean fried fish, fatty fish, or total fish intake, which were then stratified by the presence of APOE ε4. Results: Although consumption of lean fried fish had no protective effect, consumption of fatty fish more than twice per week was associated with a reduction in risk of dementia by 28% (95% CI: 0.51 to 1.02), and AD by 41% (95% CI: 0.36 to 0.95) in comparison to those who ate fish less than once per month. Stratification by APOE ε4 showed this effect to be selective to those without the ε4 allele. Adjustment by education and income attenuated the effect. Conclusion: In the Cardiovascular Health Cognition Study, consumption of fatty fish was associated with a reduced risk of dementia and Alzheimer disease for those without the APOE ε4 allele.
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U2 - 10.1212/01.wnl.0000183148.34197.2e
DO - 10.1212/01.wnl.0000183148.34197.2e
M3 - Article
C2 - 16275829
AN - SCOPUS:27644537715
SN - 0028-3878
VL - 65
SP - 1409
EP - 1414
JO - Neurology
JF - Neurology
IS - 9
ER -